AustralieFrV1, Main, Exploration, bibRecord, 007685

Non-Invasive Assessment of Small Airway Remodelling in Smokers

Identifieur interne : 007685 ( Main/Exploration ); précédent : 007684; suivant : 007686

Non-Invasive Assessment of Small Airway Remodelling in Smokers

Auteurs : Arnaud Bourdin [France] ; Tom Kotsimbos [Australie] ; Khanh Nguyen [France] ; Isabelle Vachier [France] ; Brigitte Mainprice [France] ; Martine Farce [France] ; Fabrice Paganin [Réunion] ; Charles Marty-Ane [France] ; Hélène Vernhet [France] ; Phillippe Godard [France] ; Pascal Chanez [France]

Source :

COPD : (Monticello (Sullivan County, N.Y.)) [ 1541-2555 ] ; 2010.

RBID : Pascal:10-0228517

Descripteurs français

Pascal (Inist)
- Bronchopneumopathie chronique obstructive, Bronchopneumopathie obstructive, Méthode non invasive, Fumeur, Chronique, Epithélium, Granulocyte, Neutrophile, Biologie, Interleukine 8.
Wicri :
- topic : Biologie.

English descriptors

KwdEn :
- Biology, Chronic, Chronic obstructive pulmonary disease, Epithelium, Granulocyte, Interleukin 8, Neutrophil, Non invasive method, Obstructive pulmonary disease, Smoker.

Abstract

Smoking associated COPD progression is likely to be directly linked to differential injury and repair dynamics in small airways (SA). Although IL8 is a well-accepted marker for injured airway epithelium, Clara cells [the predominant proliferating cells in SA] and SCGB1A1 protein [their major secretory product] have only recently emerged as potential SA repair markers. We therefore postulate that the SCGB1A1/IL8 ratio in the airways of smokers would be inversely associated with physiological, radiological and clinical measures of COPD. A cross-sectional cohort of 28 smokers undergoing surgery for peripheral nodule was recruited (24M/4F, age 61 ± 11 y, FEV1s 76 ± 20%, smoking 40 ± 12 p.y). SCGB1A1 and IL8 were measured by ELISA in the induced sputum (IS) 3 to 5 days prior to surgery as well as by immunohistochemistry from lung tissue (also assessed morphometrically) obtained distant to the cancer surgery site. COPD was assessed using standard clinical, functional and radiological parameters. Log-transformed IS-SCGB1A1 was linearly correlated with SCGB1A1-positive epithelial cells detected via immunohistochemistry (r = .533, p = .001), while IS-IL8 was positively related to SA infiltrating neutrophils (Elastase-positive cells). There was a striking negative correlation between IS-SCGB1A1/IL8 levels and whole airway thickness [SA < 2 mm] at morphometry (r = - 0.83, p < 0.0001). IS-SCGB1A1/IL8 levels were also inversely associated with nitrogen slope [r = -0.52, p < 0.001] and HRCT SA score [r = -0.51, p < 0.001]. In a multivariate analysis the IS-SCGB1A1/IL8 ratio was a stronger predictor than both the physiological and radiological measures of SA disease assessed. The SCGB1A1/IL8 ratio measured in sputum is a potentially valuable biomarker for non-invasive assessment of SA remodelling in smokers.

Affiliations:

Australie, France, Réunion

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biology</term>
<term>Chronic</term>
<term>Chronic obstructive pulmonary disease</term>
<term>Epithelium</term>
<term>Granulocyte</term>
<term>Interleukin 8</term>
<term>Neutrophil</term>
<term>Non invasive method</term>
<term>Obstructive pulmonary disease</term>
<term>Smoker</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Bronchopneumopathie chronique obstructive</term>
<term>Bronchopneumopathie obstructive</term>
<term>Méthode non invasive</term>
<term>Fumeur</term>
<term>Chronique</term>
<term>Epithélium</term>
<term>Granulocyte</term>
<term>Neutrophile</term>
<term>Biologie</term>
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<front><div type="abstract" xml:lang="en">Smoking associated COPD progression is likely to be directly linked to differential injury and repair dynamics in small airways (SA). Although IL8 is a well-accepted marker for injured airway epithelium, Clara cells [the predominant proliferating cells in SA] and SCGB1A1 protein [their major secretory product] have only recently emerged as potential SA repair markers. We therefore postulate that the SCGB1A1/IL8 ratio in the airways of smokers would be inversely associated with physiological, radiological and clinical measures of COPD. A cross-sectional cohort of 28 smokers undergoing surgery for peripheral nodule was recruited (24M/4F, age 61 ± 11 y, FEV1s 76 ± 20%, smoking 40 ± 12 p.y). SCGB1A1 and IL8 were measured by ELISA in the induced sputum (IS) 3 to 5 days prior to surgery as well as by immunohistochemistry from lung tissue (also assessed morphometrically) obtained distant to the cancer surgery site. COPD was assessed using standard clinical, functional and radiological parameters. Log-transformed IS-SCGB1A1 was linearly correlated with SCGB1A1-positive epithelial cells detected via immunohistochemistry (r = .533, p = .001), while IS-IL8 was positively related to SA infiltrating neutrophils (Elastase-positive cells). There was a striking negative correlation between IS-SCGB1A1/IL8 levels and whole airway thickness [SA < 2 mm] at morphometry (r = - 0.83, p < 0.0001). IS-SCGB1A1/IL8 levels were also inversely associated with nitrogen slope [r = -0.52, p < 0.001] and HRCT SA score [r = -0.51, p < 0.001]. In a multivariate analysis the IS-SCGB1A1/IL8 ratio was a stronger predictor than both the physiological and radiological measures of SA disease assessed. The SCGB1A1/IL8 ratio measured in sputum is a potentially valuable biomarker for non-invasive assessment of SA remodelling in smokers.</div>
</front>
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   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
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   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:10-0228517
   |texte=   Non-Invasive Assessment of Small Airway Remodelling in Smokers
}}

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	Serveur d'exploration sur les relations entre la France et l'Australie
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Serveur d'exploration sur les relations entre la France et l'Australie

Non-Invasive Assessment of Small Airway Remodelling in Smokers

Non-Invasive Assessment of Small Airway Remodelling in Smokers

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Descripteurs français

English descriptors

Abstract

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